Aging, Cellular Senescence, and Glaucoma

Aging is one of the most serious risk factors for glaucoma, and according to age-standardized prevalence, glaucoma second leading cause legal blindness worldwide. Cellular senescence a hallmark aging that defined by stable exit from cell cycle in response cellular damage stress. The potential mechanisms underlying glaucomatous include oxidative stress, DNA damage, mitochondrial dysfunction, defective autophagy/mitophagy, epigenetic modifications. These phenotypes interact generate sufficiently network maintain senescent state. Senescent trabecular meshwork (TM) cells, retinal ganglion cells (RGCs) vascular endothelial reportedly accumulate with age stress may contribute pathologies. Therapies targeting suppression or elimination have been found ameliorate RGC death improve vision models, suggesting pivotal role pathophysiology glaucoma. In this review, we explore biological links between specifically delving into senescence. Moreover, summarize current data on key target associated development clinical Finally, discuss therapeutic management